OUR BODY's immune response:
The bubonic plague attacks the organs associated with the lymphatic system and does this by breaking down the macrophages (cells in your immune system) in your immune system.
Once the bubonic plague enters the body through an opening, it will travel along until it reaches the immune system.
Phagocytes (Phagocytes are the cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells) are one of the innate immune system’s primary defences against extracellular bacterial infections.
Phagocytes (Phagocytes are the cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells) are one of the innate immune system’s primary defences against extracellular bacterial infections.
Observing corpses of people who had been infected with the bubonic plague, scientists noticed that there were abundant amounts Yersenia Pestis left but the surprising fact was that there were little phagocytes left. As a result, the bubonic plague was able to multiply and ultimately weaken the immune system of the victim.
Going back a bit, phagocytes are generally strong cells which help protect the body. When at 28°C, the phagocytes will actually destroy the disease before it starts to multiply. However, our core body temperature is around 37°C and at this temperature, it is able to resist the phagocytes which are trying to ingest the disease. Instead, the disease moves onto its target which are the macrophages, dendritic cells and neutrophils. The macrophages are the ultimate target for this disease. Macrophages facilitate and help multiply the disease to greater numbers in a parasitism relationship.
The proteins break down the macrophage from the inside until it is considered waste. In an attempt to discard of the said dead macrophage waste, the immune response to the disease is to exile the waste into buboes. Buboes are blister-like (in appearance) boils filled with dead macrophages that have been defiled by Yersinia Pestis.
Once the macrophages have turned into waste, the bacteria travel along the bloodstream before it blocks the arteries which often results in death if not treated quickly.
Going back a bit, phagocytes are generally strong cells which help protect the body. When at 28°C, the phagocytes will actually destroy the disease before it starts to multiply. However, our core body temperature is around 37°C and at this temperature, it is able to resist the phagocytes which are trying to ingest the disease. Instead, the disease moves onto its target which are the macrophages, dendritic cells and neutrophils. The macrophages are the ultimate target for this disease. Macrophages facilitate and help multiply the disease to greater numbers in a parasitism relationship.
The proteins break down the macrophage from the inside until it is considered waste. In an attempt to discard of the said dead macrophage waste, the immune response to the disease is to exile the waste into buboes. Buboes are blister-like (in appearance) boils filled with dead macrophages that have been defiled by Yersinia Pestis.
Once the macrophages have turned into waste, the bacteria travel along the bloodstream before it blocks the arteries which often results in death if not treated quickly.